by STOCKTON PRESS .
Written in English
|The Physical Object|
|Number of Pages||833|
Authoritative and practical, Bioconjugation: Methods and Protocols is an ideal guide for researchers looking toward precision medicine in order to expand the vital field of drug discovery. Keywords Personalized medicine Drug discovery Antibodies Antibody fragments Targeting agents Precision medicine Therapeutic compounds Scaffold proteins Antibody-drug conjugates. Provides step-by-step presentation makes the book an ideal source for researchers who are less familiar with the synthesis of bioconjugates; Features full color illustrations; Includes a more extensive introduction into the vast field of bioconjugation and one of the most thorough overviews of immobilization chemistry ever presented. This book explores conjugation strategies that are relevant for proteins used in the field of precision medicine, focusing on techniques that are suitable for antibodies, antibody-fragments such as Fabs, scFvs, or nanobodies, scaffold proteins such as FN3 or DARPin, peptides, or model proteins. Cutting-edge and highly practical, Bioconjugation Protocols: Strategies and Methods offers both novice and experienced researchers access to the broad array of techniques needed to master the semisynthesis of functional biomolecular reagents for a wide variety of applications-ranging from novel biomedical diagnostics, to powerful new.
About this book Explores bioconjugate properties and applications of polymers, dendrimers, lipids, nanoparticles, and nanotubes Bioconjugation has enabled breakthroughs across many areas of industry and biomedicine. With its emphasis on synthesis, properties and applications, . Bioconjugate Techniques, 3rd Edition, is the essential guide to the modification and cross linking of biomolecules for use in research, diagnostics, and therapeutics. It provides highly detailed information on the chemistry, reagent systems, and practical applications for creating labeled or conjugate molecules. Editorials. Delivery of Proteins and Nucleic Acids: Achievements and Challenges. We move a step closer to this goal by highlighting a series of innovative synthetic systems that show many promising attributes for safe, affordable, scalable, stable, and effective biologic and nucleic acid therapeutic advancement. This Communication reports the first general method for rapid, chemoselective, and modular functionalization of serine residues in native polypeptides, which uses a reagent platform based on the P(V) oxidation state. This redox-economical approach can be used to append nearly any kind of cargo onto serine, generating a stable, benign, and hydrophilic phosphorothioate linkage. The method.
About this book Introduction In Bioconjugation Protocols: Strategies and Methods, expert laboratorians update the classic methods and introduce valuable new approaches that go beyond basic conjugation techniques to include elements from advanced organic synthesis, molecular biology, and . Bioconjugation Protocols by Christof M. Niemeyer, Bioconjugation Protocols Books available in PDF, EPUB, Mobi Format. Download Bioconjugation Protocols books, Expert laboratorians update the classic bioconjugation methods and introduce valuable new techniques that go beyond pure biomedical applications to include elements from advanced organic. Description Bioconjugate Techniques, 3rd Edition () by Greg T. Hermanson is a major update to a book that is widely recognized as the definitive reference guide to the field of bioconjugation. To date, bioconjugation, the covalent linking of two or more biological compounds at their side ends (Hermanson, ), has been mainly limited to inorganic surfaces such as metallic nanoparticles (NPs).These strategies are known to improve stability, solubility, biocompatibility, and the interfacial activity of proteins (Canalle, Lowik, & van Hest, ; van Rijn & Böker, ).